4729-11-02 Schedule I controlled substances.

 

 

 

4729-11-02                  Scheduling of compounds.

 

 

 

(A)   The state board of pharmacy hereby schedules the following synthetic cannabinoid compounds:

 

(1)    PB-22 (chemical name: quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate) shall be a schedule I controlled substance;

 

(2)          5-Fluoro-PB-22                        (chemical               name:               quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate) shall be a schedule I controlled substance.

 

(B)   Except as otherwise provided in section 3719.41 of the Revised Code, any synthetic cannabinoid compound that meets at least three of the following pharmacophore requirements to bind at the CB1 and CB2 receptors, as identified by a report from an established forensic laboratory, is a schedule I controlled substance:

 

(1)   Aminoalkylindole compounds;A chemical scaffold consisting of substituted or non-substituted ring structures that facilitate binding of required elements (such as: indole compounds, indazoles, benzimidazoles or other ring types);

 

(2)   Alkyl or aryl side chain of four to six carbons off the indole nitrogen chemical scaffold providing hydrophobic interaction with the CB1 and CB2 receptors;

 

(3)   Carbonyl or ester or equivalent for hydrogen bonding;

 

(4)   Cyclohexane, or naphthalenalene ringnaphthalene ring, substituted butanamide or equivalent for steric requirements for CB1 and CB2 receptor binding.

 

(C)   Except as otherwise provided in section 3719.41 of the Revised Code, any synthetic cathinone that contains the structural requirements of the cathinone pharmacophore, as identified by a report from an established forensic laboratory, is a schedule I controlled substance.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

4729-11-02         Effective:	10/24/2014	2
Five Year Review (FYR) Dates:	04/17/2019
CERTIFIED ELECTRONICALLY
Certification
10/14/2014
Date
Promulgated Under:	119.03
Statutory Authority:	3719.44, 3719.28, 4729.26
Rule Amplifies:	3719.44, 3719.41
Prior Effective Dates:	4/17/2014